Substance abuse is one of the conditions responsible for the greatest burden of disability in the world, which falls mainly on those with this disorder and their families. Stigma is one of the main barriers families face, and an intersectionality-based approach makes it possible to describe the implications of addictions, considering the presence of other social determinants such as gender, poverty conditions, violence, ethnicity, and lack of access to health services. In this chapter, we use a qualitative approach to examine the experience of 12 relatives of drug users in regard to the impact of coping with drug use, and to determine whether they have been the target of stigma and discrimination. To this end, we describe the scope and limitations of this approach through an intersectional lens. Through thematic analysis, we identified five central categories in the experience of these families: (1) family history of substance use and adverse events, (2) implications of the substance abuse for the family member, (3) experiences of stigma and discrimination, (4) family resources for coping with drug use, and lastly, (5) support resources for relatives. We end by analyzing the importance of adopting an intersectional perspective to guide future interventions and support the development of family-oriented public policies.