Although there is no single definition of an ethnic minority, there is some consensus that members of an ethnic minority share a sense of belonging and linguistic and cultural backgrounds. Many minorities suffer marginalization and struggle to survive in precarious conditions that the presence of substance use problems might aggravate. In this chapter, we aim to analyze how living with a relative who consumes alcohol or other substances impacts the health of families that belong to an ethnic minority, specifically, an Indigenous community in central Mexico. The information analyzed was obtained through group interviews with members of an Otomí community in central Mexico; the majority were women aged 17–65. Five topics were addressed in the interviews: (a) How does drinking occur in the community? (b) Problems related to consumption, (c) How does it affect family members? (d) What should be done when someone drinks a lot? (e) What can be done to prevent the problem? The participants agreed that consumption patterns in the community have changed due to migration and that there are gendered social norms concerning drinking. Excessive alcohol use alters the routine and quality time spent with the family. It affects the mental health of other members, especially women, who must carry the “burden” alone and must take care of the rest of the family, including the relative who drinks. Alcohol use is accepted as part of the life of the people who live in the area, and it can become a severe problem that has equally significant consequences for the health of the person who drinks and the health of the family and the household economy, as well as having social repercussions. The views expressed by the participants must be considered to develop culturally appropriate programs to address this health problem.