Humanistic hustle has popularised a huge number of contaminants in the emerging world of environment. Presently, the most important micropollutants considered worldwide were hormone disrupting chemicals and antibiotics remarkably affects the living flora and fauna. In the present world of system, the onset and destiny of endocrine disrupting chemicals in this environment has a top solicitude for public health. In the comprehensive and investigative destiny of this situation in environment has a grid being air, water, soil, and biota computes the clear link among the hazards and its effect on humans and primitive world. Endocrine disrupting chemicals were endowed on the surface, ground and drinking water which are found in the greater extent in association with industrial pharmaceuticals effluents, heavy metals, fluorinated compounds, plastic materials, fertilizers, pesticides, herbicides and fungicides. These sewerage discharges the major sources of the therapeutic and illicit drugs, fertilizers, anti-bacterial agents for the production of hormones intended to usage of the agriculture, as personal care products and the most hazardous substances which assist in undergoing various metabolic transformations on human beings, plants and microbes for the release of hormones like hydroxy pregnenolone, dihydroxy testosterone, pregnenolone, phytoestrogens and thyroid hormones. Endocrine disruptors and antibiotics were an emerging pollutant commenced in wastewater interferes with the endocrine system and inhibits the synthesis of biomolecules in humans. Ecological, synthetic decay with few physical, chemical and biological treatments may leads to reformed articles which may or may not have chemical and biological activities. The risk associated activities and substances which are assessed are very important to detect and remove these EDCs continuously for the growth and demand of water necessity by great recycling and reusing methods of waste water. They are known to cause various human disorders which are chronic in nature. The antibiotics which are present in the waste water are ciprofloxacin, norfloxacin, tetracycline, vancomycin and β-lactams. The present chapter describes the various endocrine disruptors and antibiotics which are present in waste water for the existence of current research and literature.