The interpretationInterpretation of Mohs slidesMohs slides is the most critical step in Mohs micrographic surgeryMohs micrographic surgery (MMS). MohsMohs surgeons should be adept at identifying different cutaneousCutaneous structures and neoplasmsNeoplasm. Technical and interpretational errors are the most common causes of local recurrence after MMS. Missing a focus of tumor or interpreting slides with missing pieces of tissue can result in tumor recurrence. Consequently, MohsMohs surgeons should verify that 100% of the margin is evaluated including the entire deep margin and all the epidermal peripheries. Tumor prognosis could be dependent on the identification of certain changes in Mohs slidesMohs slides, such as angiovascular or perineural invasionPerineural invasion. On the other hand, a lack of experience in identifying cutaneousCutaneous structures such as a bulge, mantle, folliculocentric basaloid proliferationFolliculocentric basaloid proliferations (FBP) (funny follicle), or an atypical reactive endothelial cell may result in unnecessary extra stages, which would lead to unnecessarily larger defects. This negates the purpose of MMS in producing the smallest possible defect with clear margins.