Loss of facial anatomy can significantly affect the psychological well-being of patients and their quality of life. Prosthetic rehabilitation is commonly recommended in cases of disfigurementDisfigurement secondary to trauma, surgical excisionSurgical excision, congenital anomalies, or head and neck cancer. This chapter focuses on extra-oral rehabilitation associated with cancer management, summarizing the salient issues associated with craniofacialCraniofacial prosthetic rehabilitation, including the most commonly encountered treatmentsTreatment: nasalNasal, auricularAuricular, orbitalOrbital, and multisite prostheses. Additionally, this chapter explores advancementsAdvancement in prosthetic rehabilitation, including “new-age” artificial intelligence and Big Data applications.