Basal cell carcinomaBasal cell carcinoma (BCC) is the most common neoplasmNeoplasm in humans. It is also the most common indication for Mohs micrographic surgeryMohs micrographic surgery (MMS), with a 99% 5-year cure rate for primary BCCs and a 96% cure rate for recurrent BCCs. MMS is also typically the primary treatmentTreatment for more aggressive subtypes of BCC, including infiltrating, micronodular, and morpheaform subtypes. Inflammatory cells, hair follicles, and folliculocentric basaloid proliferationsFolliculocentric basaloid proliferations (FBP) are benign conditions that can resemble BCC when using horizontal frozen sectionsFrozen sections. Malignant processes, such as metastatic breast cancer, ameloblastoma, cloacogenic carcinoma, eccrine spiradenoma, pilomatricomas, and trichoepitheliomas can also mimic BCC. Additionally, BCC may differentiate to simulate many structures, such as hair follicles, sweat glands, and sebaceous glands. The evidence behind MMS for BCC is strong, with studies backed by a high number of patients and very low recurrence ratesRecurrence rates. It is especially well suited for aggressive histologic subtypes of BCC and for BCCs in anatomical regions where tissue conservation is paramount.