This research explores the intersection of neuroscience and architecture, focusing on how personality traits, including Conscientiousness, Extraversion, and Neuroticism, influence environmental perception and interaction. Intriguingly, it uncovers that these traits correlate with preferences for specific architectural styles and associated music. For instance, personalities like Openness, Conscientiousness, and Extraversion preferred coastal style, while Neuroticism uniquely favored Art Deco. Similarly, Brutalist architecture resonated with Conscientiousness, Extraversion, and Neuroticism, whereas Openness, Conscientiousness, and Agreeableness preferred the Gothic style, and the Rustic style appealed to Openness and Extraversion. Integrating virtual reality and AI, the study applied these insights in an exhibition at IncMTY, demonstrating the practical implications of personalized design in enhancing well-being and efficiency. This approach highlights the significant benefits of tailored design in diverse settings and analyzes the interplay of digital personality traits and describes the potential of tailored interactive experiences in fields like education or manufacturing. It addresses the challenges of technological complexity and cross-disciplinary collaboration, advocating for a shift towards more human-centric design.