Universities have an essential role in achieving the SDGs. Management and control of water and wastewater resources based on swampland adaptation is the 6th SDGs, Clean Water and Sanitation, and the 13th SDGs, Climate Action. This paper examines water resources management based on wetland adaptation in the urban campus area of UIN Raden Fatah Palembang (UINRFP). The research used primary and secondary data and conducted water and wastewater laboratory tests and data analysis. Rainwater harvesting is carried out to prevent flooding on the campus, as well as to provide water reserves for life. The volume of rainwater harvested and stored in campus water canals is 30,424 m3/year, a potential economic water reserve and renewable energy source. Construction techniques with precast concrete pit foundations type squares pile a 32–40 m 1461 in all campus buildings and utilities. The construction technique is a solution for urban swampland adaptation, estimated to withstand water infiltration at a slow rate of 3357.5 m3. The Sewage Treatment Plant (STP), with a capacity of 506 m3, was built to treat domestic wastewater. Domestic wastewater is collected in 25 ground tanks (capacity 2–21 m3) and channeled to STP for further processing. After meeting quality standards, it is stored in a retention pond to become campus reserve water. The quality of water resources is tested in periodic laboratories; all test results meet water or wastewater quality standards. Water resources and their management on the UINRFP campus as a potential water reserve of 75,171 m3 for micro-hydro power generation, raw-clean water, drinking water production for campus needs, and even business unit development. Through the above efforts for efficiency, conservation, and usability of water resources, the university contributes to reducing the impact of climate change.