The climatic emergency, characterised by the progressive increase in climatic variations and changes in atmospheric conditions, positions the Mediterranean city and its constituent architecture as a privileged site for experimenting with new distributional and physiological approaches, maintaining a constant interaction with climate and the environment. Investigating the contemporary relationship between climate and architecture within the Mediterranean geo-climatic context is fundamentally important, as the Mediterranean region has been identified as one of the primary hotspots of ongoing climate change. Indeed, the anomalous warming of the Mediterranean Sea in 2022, documented by the European Union’s Earth monitoring program, Copernicus, represents a concerning reality, impacting not only marine ecology and coastal ecosystems but also posing direct and indirect implications for architecture. In the region surrounding the Mediterranean Sea, influenced by climatic conditions such as intense sun exposure, water temperature and air flows, architecture has maintained specific building approaches over the centuries essential for ensuring a minimum level of living comfort. Due to the unique characteristics of this region, stereotomy has found widespread application, playing a significant role in mitigating climate impacts. Given this high scenario, a local approach to understanding and analysing climatic phenomena within the urban system is crucial to prevent weather and climate variations from escalating into disasters. Hence, there is a need to define design actions that can empower contemporary architectural design to withstand weather and climate variations. The architectural project must, therefore, establish reactive-programmatic actions: actions capable of enduring changes dictated by external stresses, while recognising the opportunities that may arise from them. The design process must give rise to an open system capable of accommodating changes and new information, establishing connections between problems and solutions to anticipate possible contextual variations and being prepared for unexpected events. In this perspective, architecture assumes a fundamental role through the implementation of strategies, defined here as design actions. The present contribution aims, therefore, to provide an interpretation and definition of the relationship between the climatic emergency and architecture in the Mediterranean geo-climatic context, contributing to the identification of new tectonic devices capable of resisting climatic variations in Mediterranean cities and simultaneously generating new urban microclimates.