The chapter deals with some studies carried out at the University of Naples regarding the potential of changing the usual approach to mitigation and adaptation measures against climate change negative effects. The research presents innovative solutions aimed at both reducing the risk potential and safeguarding the identity and ecosystems of the interested bioregion. The main objective is to define a new approach to the subject of Climate Change struggle within urban areas at risk, which involves an in-depth examination of complex environmental issues as well as new bioregional solutions rather than merely accepting global programmes, not always fully appropriate to the bioregion. New York faces flood risk, mainly in the coastal areas due to its geographical location, as far as floods due to sea level rise and extreme weather are concerned. Areas at risk include low-lying areas of the city, such as Lower Manhattan, Brooklyn and Queens along the coastal zones. The here presented research methodology applies an enlargement of the analysis process upon the case study—a small portion of the Manhattan waterfront—and a deep study of the place’s identity and meaning, and then some technical and design strategies are proposed. New solutions are studied by taking into analysis a small stretch of coastline, close to the mouth of the East River and the construction of new piers is designed that significantly improve waterfront public use and enjoyment. By extending these platforms, the chance of allocating this space to scenic promenades results and raising them can mitigate flood risk. Such modifications, through the design of an appropriate slope, avoid the construction of a wall with the function of a barrier that would obstruct light and air or the view of the waterfront from neighbouring properties and visual corridors. The results show the great distinction between the various technical solutions defined by the American programmes and those selected for the present study, due indeed to the fact that the here proposed ones are strongly in line with the bioclimatic and bioregional approach.