Job crafting is an innovative approach that increases job satisfaction and effectiveness, enabling employees to modify their roles, tasks, and interactions to align with their abilities and aspirations. Objective: Examine job crafting in healthcare, focusing on its application, development, and implementation possibilities and challenges. Method: A systematic review in November 2023, following PRISMA guidelines, investigated “job crafting” among health professionals across Pubmed, ScienceDirect, Scopus, Web of Science, and Google Scholar. It excluded non-relevant or non-health professional studies. The review focused on studies’ publication years, geographies, participant types, designs, theoretical frameworks, potentials, dimensions, barriers, and tools, specifically within healthcare settings. Results and Discussion: The review found 27 articles, mainly from the Netherlands, focusing on nurses and using quantitative analysis with the Job Demands-Resources model. The Job Crafting Scale was frequently used to study the link between job crafting and engagement. Although detailed information on barriers to implementation is scarce, the presence of organizational, individual, and contextual hurdles suggests a significant research opportunity to explore these implementation challenges further. Conclusions: Research on job crafting in healthcare, mainly among nurses, utilizes the JCS and quantitative methods, but they miss barrier analysis, suggesting a need for more detailed research on influencing factors.