In philosophy of science, discussions of explanation are often restricted to causal or causal-mechanical explanations. Some have called these explanations “answers to why-questions”. In this chapter, I suggest going beyond explanations thus defined. I propose a workflow-based framework for explanation and how it is used in medicine and public health. This proposal covers epistemic, justificatory, methodological, and anticipatory explanations, each of which appears twice (resulting in eight explanatory functions) in a cycle that starts with problem definition and proceeds to intervention, evaluation, and assessment.