In this chapter, I bring together the concepts of etiological explanation and explanatory-predictive coherence by offering a proposed outline for a multi-evidence map, in which evidence of association, biology, confirmation, and difference can be documented with the goal to reduce interventional uncertainty. Moreover, I also proposed that high quality evidence that is mutually supportive and non-contradictory might be a good starting point for judging the degree of explanatory-predictive coherence. More work is needed to outline formal ways to extract evidence from the literature and organize it using evidence mapping to curb interventional uncertainty and justify interventions in medicine.