Venous leg ulceration (ulcer) (VLU) is the most severe symptom of chronic venous insufficiency, accounting for 70–80% of all lower limb ulcerations. Typically, about 80% of VLUs are located around and above the medial malleolus and below the bulge of the gastrocnemius muscles, where venous pressure is maximal due to the underlying presence of large perforating veins. VLUs are defined as an area of discontinuity of the epidermis of the leg that fails to heal spontaneously and is sustained by chronic venous disease. One percent of all people in industrialized countries will suffer from a leg ulcer at some time during their lives. In Western countries, the patient prevalence of active leg ulceration is about 1.5/1000. Prevalence increases with age to 4–5% of the population ≥ 80 years, reflecting the chronic recurrent nature of the condition. VLUs also have a significant impact on the social burden. VLUs significantly decrease the quality of life, and they could even cause social isolation and depression and negatively affect mobility, employment, and physical activity. They also have a significant impact on the economic burden. The treatment of venous ulceration accounts for around 3% of the total expenditure on health care.