Peripheral artery disease (PAD) is a major public health and medical concern in both developed and developing countries. For example, in Western Europe the prevalence of PAD is estimated to be between 4% and 8%. In 2017 it was estimated to affect approximately 19.8 million people in the United States. Approximately 40% of these individuals have common PAD symptoms such as leg pain. Of patients between age 50 and 69, and more significantly over 70 years of age, with a history of smoking and diabetes, 29% will manifest PAD. The mortality and morbidity of patients with PAD is high. Endovascular treatments can include balloon angioplasty (with or without drug coating), with or without stent placement (bare metal, covered, drug coated, self-expanding, or balloon expandable), at times in combination with atherectomy. Surgical procedures provide an alternative to endovascular therapy in select cases. The most appropriate treatment modalities in any individual case are influenced by a variety of factors. These factors include lesion length, location, configuration, composition, degree of calcification, as well as patient comorbidities. In this book chapter, we will review the latest Evolving Technology for Peripheral Artery Disease Treatment and discuss latest study results.