Peripheral artery disease (PAD) has a heritable component and susceptibility to PAD may be influenced by genetic variants. Identification of genetic variants and other ‘omic’ markers can provide insights into underlying pathophysiologic mechanisms and facilitate the development of novel risk assessment and therapeutic approaches. In contrast to coronary heart disease, fewer genetic susceptibility variants for PAD have been discovered, likely due to greater clinical and genetic heterogeneity in PAD. In this chapter, we review the multiomics basis of PAD, including genomic, epigenetic, proteomic, and metabolomic markers.