This article addresses the issue of how the efficiency of information interaction among participants in the supply chain impacts the overall efficiency of the supply chain itself. By considering the information flow of the supply chain as a holistic process of interaction among participants' information systems, approaches to harmonizing such interaction based on existing international, regional, and industry standards are analyzed. Semantic graphs are explored as a tool for such harmonization, enabling the representation of interconnected data models and requirements within the contexts of specific supply chain participant systems. A key factor influencing the choice of approaches and analysis methods for this issue is the factor of information security and supply chain security as a whole, including constraints such as data sovereignty, restricted access to internal information models of participant systems, and high inertia of adapting large computing systems to evolving requirements. One of the approaches considered to address these factors is the concept of data pipelines.