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P2Y receptors represent a class of purinergic receptors distributed across the human body, mainly involved in various physiological processes. These belong to the family of G protein-coupled receptors (GPCRs). Activated by nucleotides such as ATP and ADP, this family has eight distinct subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). They play diverse functions in neurotransmission, immune modulation, and glial transmission by controlling neurotransmitters and neuronal excitability. Their implication in many neurodegenerative diseases like epilepsy, Alzheimer’s and Parkinson’s disease, as well as neuropathic pain, makes them an important therapeutic target.

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P2Y Receptor Endocytosis and Signaling

  • 章节

  • 发表日期：

    2025年

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  • Biswas Krittika,
  • Mukherjee Mohima,
  • Bhavani S. Sahu

摘要

P2Y receptors represent a class of purinergic receptors distributed across the human body, mainly involved in various physiological processes. These belong to the family of G protein-coupled receptors (GPCRs). Activated by nucleotides such as ATP and ADP, this family has eight distinct subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). They play diverse functions in neurotransmission, immune modulation, and glial transmission by controlling neurotransmitters and neuronal excitability. Their implication in many neurodegenerative diseases like epilepsy, Alzheimer’s and Parkinson’s disease, as well as neuropathic pain, makes them an important therapeutic target.