Digital microfluidic biochips have replaced traditional biomedical analyzers and offer the capability of perfect integration of a wide range of biomedical functions required for diverse bioassay operations. Over the past two decades, microfluidic biochips have gained significant interest in various healthcare sectors, such as DNA analysis, clinical diagnosis, and drug discovery. Biochip devices have been widely accepted and adopted for their potential contributions to these fields. Considering their utilization in safety-critical applications, clinical diagnosis, and real-time biomolecular assay operations, these devices must possess essential qualities such as precision, reliability, and robustness. In order to be deemed suitable for discriminating purposes, a microfluidic device must demonstrate its correctness and durability through an exceptional testing strategy. In this paper, we have proposed an efficient multi-droplet traversal technique to identify several defective electrodes in a digital microfluidic biochip. This technique combines boundary traversal and inner traversal procedures to visit each electrode and its connections of the device. Additionally, our approach accurately calculates the traversal time for a fault-free biochip.

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Multiple Faults Detection Technique by an Efficient Traversal Approach Using Multiple Droplets for Digital Microfluidic Biochip

  • Basudev Saha,
  • Utpal Mandi,
  • Mukta Majumder

摘要

Digital microfluidic biochips have replaced traditional biomedical analyzers and offer the capability of perfect integration of a wide range of biomedical functions required for diverse bioassay operations. Over the past two decades, microfluidic biochips have gained significant interest in various healthcare sectors, such as DNA analysis, clinical diagnosis, and drug discovery. Biochip devices have been widely accepted and adopted for their potential contributions to these fields. Considering their utilization in safety-critical applications, clinical diagnosis, and real-time biomolecular assay operations, these devices must possess essential qualities such as precision, reliability, and robustness. In order to be deemed suitable for discriminating purposes, a microfluidic device must demonstrate its correctness and durability through an exceptional testing strategy. In this paper, we have proposed an efficient multi-droplet traversal technique to identify several defective electrodes in a digital microfluidic biochip. This technique combines boundary traversal and inner traversal procedures to visit each electrode and its connections of the device. Additionally, our approach accurately calculates the traversal time for a fault-free biochip.