Nowadays, Blockchain is generating the interest of diverse companies in implementing it. This technology could generate various advantages by applying cryptocurrencies, smart contracts, decentralized applications (Dapps), or Non-Fungible Tokens (NFTs) to firms. Still, enterprises do not have sufficient information to develop this potential technology, and there are many challenges they need to solve, such as technological, organizational, environmental, human, or Sustainability. For this reason, it proposes a strategic approach for organizations to implement Blockchain, transforming their business models. Moreover, this research applies design science methodology, generating a new BusinessMmodel Canvas for creating innovative and disruptive businesses with Blockchain implementation in tourism companies. Furthermore, this paper helps firms obtain more information about the performance of Blockchain and how this disruptive technology makes value in their business. This work brings insights to academics and researchers to develop future business models implementing Blockchain through another type of research, like the design science approach.