Cassava Mosaic Begomoviruses (CMBs) are plant viruses that affect cassava (Manihot esculenta), a critical sustenance crop in many tropical and subtropical regions of the world. Multiple species of begomoviruses, a type of geminivirus, are responsible for the cassava mosaic disease. CMBs are members of the Geminiviridae family and are persistently transmitted by whiteflies (Bemisia tabaci), indicating that the virus can remain in the insect for an extended period and be transmitted to multiple plants. These viruses cause yellow mottling, curling, and distortion of cassava leaves, resulting in reduced plant growth, decreased root yield, and possibly plant death. African cassava mosaic virus (ACMV) is a widely studied begomovirus that infects large-scale cassava plants in Africa. It is one of the principal pathogens responsible for cassava mosaic disease (CMD), which poses a significant hazard to cassava production by inducing filiform-shaped leaves. Whiteflies, specifically B. tabaci, are responsible for transmitting ACMV, similar to other geminiviruses. Once infected, cassava plants exhibit symptoms, such as yellow mottling, leaf arching, and leaf distortion, which can drastically reduce plant growth, root production, and overall productivity. Disease severity varies depending on the viral strain, environmental conditions, and the resistance or susceptibility of the host plant.