Rhizopus is a genus of fungi that belongs to the phylum Zygomycota. It is commonly known as bread mold or black mold. Rhizopus species are found worldwide and are typically saprophytic, meaning that they obtain nutrients by decomposing organic matter. The life cycle of Rhizopus involves both sexual and asexual reproduction. Under favorable conditions, it reproduces asexually through the formation of sporangiospores. Rhizopus species can also act as plant pathogens and cause diseases in various crops. One of the most notable diseases caused by Rhizopus is Rhizopus soft rot, also known as Rhizopus rot or Rhizopus crown rot. This disease primarily affects fruits and vegetables including strawberries, tomatoes, cucumbers, and peppers. This chapter delves into the biology and pathology of Rhizopus and explores its taxonomy, geographical distribution, transmission, host range, symptomatology, pathogenicity, isolation and identification, detection, epidemiology, economic importance, and control measures. By understanding the intricacies of this devastating plant pathogen, we can better protect crops and mitigate the economic losses associated with Rhizopus infections.