Coffee rust, also known as coffee oriental leaf rust, caused by Hemileia vastatrix, is a devastating fungal disease that affects coffee plants. This is one of the most significant threats to coffee production worldwide. This disease primarily affects the leaves of the coffee plants. Coffee leaf rust can cause significant damage to coffee plantations, leading to yield losses and economic hardships for coffee farmers. It can reduce coffee production, affect bean quality, and kill young coffee plants. Coffee leaf rust outbreaks have historically led to fluctuations in global coffee prices, affecting coffee markets and the livelihoods of millions of people in the coffee industry. Therefore, efforts to combat and manage this disease are critical for ensuring the sustainability of coffee production. Managing coffee rust can be challenging and usually involves a combination of approaches including cultural, chemical, and genetic methods. Farmers may use fungicides to control the spread of the disease; however, this can be costly and may have environmental implications. Planting rust-resistant coffee varieties is crucial for long-term management.