The paper focuses on optimizing coating efficiency in pharmaceutical tablet production. Coating tablets with active pharmaceutical ingredients (APIs) is crucial for controlling release rates. The process involves spraying a liquid onto a mixed tablet bed, where it forms a solid coating through evaporation. Homogeneity in coating thickness is vital for consistent API release. The study proposes a Monte-Carlo model for a rotary drum spray coater. Experimental validation shows good agreement between simulated and observed coating thickness distributions. Based on the proposed model different real-time optimization algorithms are explored to improve coating efficiency. Results highlight the importance of optimizing coating parameters for efficient and uniform tablet production, crucial for pharmaceutical quality control and cost-effectiveness.