Safety at workplaces has become a major concerns to the global community as it poses a threat to sustainable development. Workplace safety can be maintained and improved through a synergistic effect of human factor engineering and innovation. This study was aimed at leveraging the unique expertise of academia, industry, and government in proposing a comprehensive framework for reducing workplace accidents and enhancing overall safety in the workplace. Systematic process approach was used for collection and analysis of data. Literature on workplace safety, innovation, human factor engineering and triplex helix model were retrieved during the study. About 42 journals and articles were downloaded and reviewed; 35% of the articles were workplace safety and human factor engineering, 26% were innovation, 18% were triple helix model while 21% were general literature related to collaboration, occupational health and safety and case studies. The study revealed that technological innovation such as Underground Utility Damage Prevention (UNDP) processes, Drones, Unmanned Aerial Vehicles (UAVS), Realistic gaming software, Video Task Hazard Analysis (THAs) techniques, Safety apps, Smart wearable sensors, Virtual reality (VR) and augmented reality (AR) technologies, Artificial intelligence (AI) and algorithms, Internet of Things (IoT) and machine learning (ML) technologies are used to manage workplace safety and achieve loss prevention. Workplace innovation centers on workplace, organisational and management task designs to meet workplace safety, workers quality life and organisational performance. Government has responsibility to develop policies and regulations for adoption of safety innovations, National safety profile, codes of practice and technical standards, monitor compliance, develop safety curricula, promote and support researches in safety, enact patent laws that protect innovators, establish safety data collection system, consult stakeholders and mainstream safety into educational sector. Application of ergonomic principles, human factor engineering methodologies, biomechanics, user-centered design and cognitive engineering optimizes interaction between workers and their environment resulting in workplace accident prevention. Industry should develop facilities for practical research purposes while higher educational institutions should accept industries as credible partners in commercializing research outcome. We recommend that future research be done on the scalability of this kind of collaboration in developing countries.