Formation of a holistic view of the financial security management of enterprises in uncertain conditions, taking into account systemic, process, mechanistic, and strategic approaches. The informational basis of the research is the works of modern scientists, which contain materials that characterize the content and components of managing the financial security of the enterprise and also serve as a way of creating initial ideas and an original concept about the protection of the economic entity from dangers and threats. The research methodology includes the use of a set of general scientific and private scientific, theoretical, and empirical methods of cognition, which are based on categories and principles of dialectics, which makes it possible to consider the financial security management of the enterprise based on different approaches. Scientific approaches to the interpretation of the concept of “the financial security management of the enterprise” are summarized and considered. The purpose, tasks, and principles of financial security management at the micro level are determined. An infological model of the financial security management of the enterprise is developed, and it was built taking into account systemic, process, mechanistic and strategic approaches. As a result of the study, it was proved that the financial security management of the enterprise is a set of consistent and interconnected methods, forms, tools and levers for the protection of its financial interests from dangers and threats of an external and internal nature through the development and implementation of management decisions aimed at creating prerequisites for growth of market value and sustainable development in the current and prospective periods. The existing approaches to the financial security management of the economic entity are studied and systematized; their conceptual and categorical apparatus are revised and rethought, and a methodological basis for adapting the enterprise’s activities to conditions of uncertainty is formed to ensure the unity of approaches in the development of a new paradigm of financial security management. The theoretical results and methodological provisions of the research are brought to the level of specific proposals and methodological developments that can be used by economic entities in the implementation of financial security management in conditions of uncertainty.