Brazil leads global soybean production, Glycine max (L.) Merr., meeting 36% of the world’s demand. Soybeans are useful as a vital source of vegetable protein, catering to diverse industries including food, biodiesel and meat production. However, the expansion of soybean cultivation faces challenges due to phytosanitary threats, particularly stink bug pests. The principal stink bug pest in the neotropical region is Euschistus heros, whose control still is heavily dependent on chemical control methods. However, such practices have shown limitations in efficacy, including association with insecticide resistance. Emerging technologies like RNA interference (RNAi) offer promising avenues for crop protection, including the biorational control of stink bugs. RNAi enables gene silencing and can be deployed through plant-incorporated protectants (PIPs) or spray-induced gene silencing (SIGS). While transgenic RNAi crops initially dominated, non-transformative SIGS techniques provide faster alternatives, bypassing the lengthy development process of genetically modified (GM) crops. RNAi-derived crop varieties have streamlined global regulatory frameworks, enhancing their adoption. In SIGS, attention shifts to stabilization of formulation and environmental risk assessments (ERAs) for RNA-based formulations. Common to both approaches is the need to evaluate environmental impact, ensuring minimal harm to non-target organisms (NTOs), including parasitoids, predators and beneficial arthropods such as pollinator bees. This chapter highlights the application of RNA-based biorational pesticides in soybean farming, highlighting benefits such as overcoming insecticide resistance and synergistic compatibility with natural enemies to control stink bugs infestations.