Digital transformation, in both public and private life, leads to an extensive use of digital technologies in communication. Apart from other communication channels, social media is the most popular platform for politicians, public institutions, and citizens to seek, discuss, and exchange information. However, this intensive use of social media also has a negative impact in the form of harmful content sharing, mostly called disinformation. The chapter examined the life cycle of disinformation in its theoretical and practical meaning. Previous research was investigated to demonstrate the relationship between digital transformation and disinformation and identify the key states of the disinformation’s life cycle. Throughout the period from 2020 to 2024, a total of 18 case studies on disinformation were analyzed, focusing on the four key phases of disinformation’s life cycle: creation, spreading, impact, and response. Cases selected by multicriterial selection were categorized by the year of their appearance and content, including disinformation regarding the provision of public services, crisis situations, and management of public institutions. The digital transformation has accelerated the creation and dissemination of disinformation, but it also presents various systematic and ad-hoc opportunities to minimize its negative impact on public institutions.