Intraocular tumor resection methods include iridectomy; iridocyclectomy; trans-scleral choroidectomy, also known as exoresection; and trans-retinal choroidectomy, also known as endoresection. Iridectomy is performed with preservation of the iris sphincter if this is not involved by the tumor. Iridocyclectomy is done with a lamellar scleral flap, hinged at the limbus. Trans-scleral choroidectomy involves preparation of a lamellar scleral flap, core vitrectomy, excision of the tumor together with the attached deep scleral lamella, intraocular injection of balanced salt solution after the closure of the scleral flap, and adjunctive radiotherapy. With endoresection, the tumor is removed with a vitreous cutter that is passed through a large retinotomy, and then laser retinopexy and fluid–silicone exchange are performed to prevent retinal detachment and postoperative hemorrhage. The most serious complications are local tumor recurrence, avoided by adjunctive radiotherapy; rhegmatogenous retinal detachment after exoresection; and fatal gas embolism after endoresection. For these reasons, resection of intraocular melanomas is usually reserved for tumors that are not suitable for radiotherapy.