Animal models are invaluable in increasing our understanding of tumor biology, growth, and metastasis, as well as in helping to establish novel therapies against human malignancies. This chapter provides an introduction to the types of animal models that have been established for studying uveal melanoma (UM). Animal models in UM can be grouped into the following categories: spontaneous models, syngeneic models, xenotransplantation models, transgenic models, and induced models. We focus on a general classification of these model types, as well as on summarizing the advantages and limitations of each model and their application to studying specific aspects of the disease. This is followed by a discussion on how we can interpret results from animal studies to better understand several aspects of UM, with a focus on primary ocular disease, the natural history of UM, cancer angiogenesis and immunology, tumor dormancy, metastasis, liquid biopsy, and treatment strategies. Many attempts have been made to create optimal models that mimic UM biology, disease course, and metastasis, but challenges remain in imitating the genetic, histologic, immunologic, and metastatic features of UM. However, while no one model is ideal, each model provides certain benefits that make it appropriate to answer specific scientific questions. When the proper model is selected to mimic specific aspects of the disease, animal models can serve as powerful tools to investigate the biology of UM and identify novel therapeutic approaches.