This chapter delves into the diverse landscape of healthcare simulation modalities, categorizing them into two primary types: physical simulation and digital simulation. Physical simulation includes task trainers, manikins, and standardized patients, each offering distinct advantages and disadvantages. Task trainers, cost-effective and portable, excel in specific skill practice. Manikins, ranging from low to high fidelity, simulate various patients for comprehensive training. Standardized patients, skilled actors representing patients, enhance communication and examination skills. The digital realm introduces extended reality (XR) modalities, including virtual reality (VR), augmented reality (AR), and mixed reality (MR). These digital simulations enable immersive, safe, and versatile training experiences. The chapter explores the benefits and applications of each modality, emphasizing the importance of aligning the choice with learning objectives, resource availability, and learner needs.