Medicine is being logically deduced from its roots, i.e., actual, or potential biological negativities such as suffering, discomfort, and harm which play a pivotal role in the normal/abnormal divide, that is in the theoretical articulation of medical concepts. This chapter introduces the primary features from which medical thinking is being deduced, namely the biological roots of medicine: suffering, discomfort, and harm, which play a pivotal role in the normal/abnormal divide, that is, in the theoretical articulation of all medical concepts. The concept of “disease” does not belong to the starting point of medicine, but it represents a useful construct that helps to codify he brute clinical data. Medicine grew out of the fundamental call for the alleviation of suffering or potential suffering (be it physical or mental) and their consequential role in construing the normal-pathological divide.