The further away we move from the clinical and theoretical core of medical thinking, the closer we get to the confines of medicine. Yet, medicine like any professional discipline, needs confines, which must rely on cases in which an individual becomes a casualty of some condition of his own body or mind. These confines may be epistemic, ethical, or ontological, and going further beyond these limits belong either to medicalization or to medical enhancement. When medicine reaches its limits, its objectives dissolve by the incursion of legal, political, existential, anthropological or new ethical concerns that interpose into the central core of medical thinking. Clinical knowledge is knowledge by participation so that clinical apprehension is likely to be governed by the doctor’s interest, experience, knowledge and emotions.