Neurorehabilitation practices can be potentiated by incorporating neurorehabilitation technologies designed to facilitate personalized, engaging, focused, intense, varied, and task-specific training. A selected set of technologies that specifically target sensory-motor training are briefly presented, their use to potentiate activity-dependent neuroplasticity is described, and the clinical evidence of their use by individuals affected by different neurological conditions or injuries is summarized. These technologies encompass functional electrical stimulation (FES), robotic-assisted training, biofeedback, brain-computer interfaces (BCI), virtual reality (VR), augmented reality (AR), noninvasive brain stimulation (NIBS), body weight supported training (BWST), wearable sensors, and home-based training. When integrating neurorehabilitation technologies into rehabilitation scenarios, opportunities to improve outcomes and challenges associated with their use arise. These are presented along with a series of final reflections about future research directions and applications of neurorehabilitation technologies conclude this chapter.