Emotional expressions, proposed by Darwin in 1896 as inherited motor patterns, have since been confirmed as universal across cultures, indicating a genetic basis. These expressions, like fear, anger, joy, and sadness, facilitate social communication and bonding. Physiological responses, behavioral reactions, and conscious experiences form the basis of emotional processing, with the amygdala playing a central role in integrating these aspects. In neurorehabilitation, emotional expressions provide insights into motor control and response to stimuli. Lesions affecting emotional control areas can result in socially inappropriate responses, but training can improve emotional regulation. Emotional experiences influence decision-making processes, mediated by connections between the ventral-medial forebrain and prefrontal cortex. Emotional decision-making, often rapid and unconscious, is vital for adaptive behaviors. Depression commonly accompanies brain injuries, impacting rehabilitation outcomes. Early detection and treatment of depression are essential for effective rehabilitation. Challenges arise from motivational deficits in depressed individuals, emphasizing the importance of addressing mental health alongside physical recovery in neurorehabilitation.