Silver nanoparticlesNanoparticles have immense potential to enable new technologies across many biomedical fields, ranging from tracking and delivery of drugs, bio-imaging and bio-sensing, diagnosis and treatment, tissue engineering, and biomedical implants. Metallic nanomaterialsNanomaterials, particularly silver, have proven to exhibit antiviral activities against a broad spectrum of viruses. Silver nanoparticlesNanoparticles have been known for decades to display antiseptic characteristics, including antibacterial, antifungal, and antiviral properties. They are efficient in wound management, various coatings for medical devices, and impregnating textile fabrics. We describe here a scalable approach to create high-performance nanoparticleNanoparticles-mediated surfaces that could potentially modulate and deactivate microbial contaminants, therefore eliminating the spread of diseaseBio-medical devices.