Gastric cancer, ranking as the sixth most prevalent cancer globally and a leading cause of cancer-related mortality, follows a sequential progression known as Correa's cascade, spanning from chronic gastritis to eventual malignancy. Although endoscopy exams using Narrow Band Imaging are recommended by internationally accepted guidelines for diagnostic Gastric Intestinal Metaplasia, the lack of endoscopists with the skill to assess the NBI image patterns and the disagreement between endoscopists when assessing the same image, have made the use of biopsies the gold standard still used today. This proposal doctoral thesis seeks to address the challenge of developing a Computer-Aided Diagnosis solution for GIM detection in NBI endoscopy exams, aligning with the established guidelines, the Management of Epithelial Precancerous Conditions and Lesions in the Stomach. Our approach will involve a dataset creation that follows the standardized approach for histopathological classification of gastrointestinal biopsies, the Sydney System recommended by MAPS II guidelines, and annotation by gastroenterology experts. Deep learning models, including Convolutional Neural Networks, will be trained and evaluated, aiming to establish an internationally accepted AI-driven alternative to biopsies for GIM detection, promising expedited diagnosis, and cost reduction.

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Towards Non-invasive Detection of Gastric Intestinal Metaplasia: A Deep Learning Approach Using Narrow Band Imaging Endoscopy

  • Sílvio Capela,
  • Jorge Lage,
  • Vítor Filipe

摘要

Gastric cancer, ranking as the sixth most prevalent cancer globally and a leading cause of cancer-related mortality, follows a sequential progression known as Correa's cascade, spanning from chronic gastritis to eventual malignancy. Although endoscopy exams using Narrow Band Imaging are recommended by internationally accepted guidelines for diagnostic Gastric Intestinal Metaplasia, the lack of endoscopists with the skill to assess the NBI image patterns and the disagreement between endoscopists when assessing the same image, have made the use of biopsies the gold standard still used today. This proposal doctoral thesis seeks to address the challenge of developing a Computer-Aided Diagnosis solution for GIM detection in NBI endoscopy exams, aligning with the established guidelines, the Management of Epithelial Precancerous Conditions and Lesions in the Stomach. Our approach will involve a dataset creation that follows the standardized approach for histopathological classification of gastrointestinal biopsies, the Sydney System recommended by MAPS II guidelines, and annotation by gastroenterology experts. Deep learning models, including Convolutional Neural Networks, will be trained and evaluated, aiming to establish an internationally accepted AI-driven alternative to biopsies for GIM detection, promising expedited diagnosis, and cost reduction.