This chapter summarizes the history of earthquake monitoring and the recent advances in the seismic networks in Egypt, Saudi Arabia, the Sultanate of Oman, and the United Arab Emirates (Abu Dhabi). Real-time seismic monitoring systems enhance emergency response and, in some cases, short-term mitigation and preparedness. Many earthquakes prone nations are beginning to develop and use rapidly emerging technology of real-time seismic monitoring and early warning systems. The main function of real-time seismic monitoring systems is to provide information on the location, magnitude, frequency of occurrence, and duration time. Seismic monitoring systems must be technologically sophisticated and fundamentally adequate to meet important needs for public safety and emergency management, quantify hazards associated with natural and artificial earthquakes, and engineering applications. The first step toward establishing a new seismic network is understanding and setting the network’s goals. To better understand the seismicity, a denser seismic network is required to locate the hypocenter accurately, examine the fault plane solution, and evaluate the seismic hazard. Subsoil conditions such as the sediments’ stratigraphy, distribution, and dynamic behavior should be studied in detail. Regional cooperation is very important for getting more accurate location for epicenters.