This chapter provides an in-depth examination of the critical importance of travel path attenuation in the field of seismology. It places particular emphasis on areas that are subject to active tectonic movements, like the East Mediterranean and the Red Sea regions. This aims to shed light on how seismic waves diminish in intensity as they traverse through various geological structures in these dynamically evolving zones. Path attenuation, which encompasses the study of seismic wave propagation and its impact on observed seismic phenomena, is crucial for precise seismic hazard assessments and the engineering of earthquake-resistant infrastructure. The high seismic activity in these regions, due to the interactions between the Arabian and Africa Nubian Plates, emphasizes the importance of investigating path attenuation for effective hazard prediction. Through a review of scholarly research on path attenuation in these geologically complex regions, this chapter aims to contribute to the advancement of seismological knowledge and the enhancement of seismic hazard forecasts. By elucidating the complexities of seismic wave propagation, this chapter supports efforts to strengthen resilience to seismic disturbances and mitigate the potential risks posed by earthquakes in these vulnerable areas.