The East Anatolian Fault Zone (EAFZ) is the Anatolian region’s most significant active tectonic unit. Devastating earthquakes were reported on EAFZ throughout history. Kahramanmaraş doublet earthquakes on February 6, 2023 showed that this fault zone can cause a devastating earthquake (with Mw 7.7 and Mw 7.6). This earthquake caused damage in cities located close to the EAFZ. Kahramanmaraş is located just west of the EAFZ and the city is situated on the Kahramanmaraş Fault Zone. While earthquake hazard is related to the distance to fault zones, earthquake risk is also characterized by geological features and local soil properties. In addition, local soil properties directly affect the characteristics of ground motion. Soil amplification estimation is of great importance for geosciences and geotechnical studies. This study aims to assess the regional damage after Kahramanmaraş doublet earthquakes (on February 6, 2023) with vulnerability index (Kg). For this purpose, 56 three-component earthquake data from 10 acceleration stations located in Kahramanmaraş city center were analyzed by using the Nakamura method on earthquake records. Kg values were determined using the soil dominant frequency and amplification factor (H/V spectral ratio). In the final step damage estimates from satellite data, post-earthquake satellite images, and Kg values were compared. A positive correlation was observed between high Kg values and earthquake-damaged regions. In addition, the study also evaluated other parameters that may affect and explain regional damage, such as the response spectra of the two main shocks (according to the Turkish Building Earthquake Code) and Vs30 values. Kg values in a region can be used to predict the regions with the potential to be damaged in a future possible earthquake and contribute to risk mitigation efforts.