Manufacturing faces significant sustainability challenges due to its intensive consumption of natural resources. The paradigm of sustainable manufacturing stood out in recent years, prompting the development of various tools and methodologies to assess the sustainability performance of manufacturing activities. These tools often evaluate environmental, economic, and social impacts based on the Triple Bottom Line (TBL) framework. However, their practical application remains limited due to scalability issues (with few tools addressing entire manufacturing systems), sector-specific designs, and challenges in the comparability of results. The adoption of the Best Available Techniques (BAT) framework has also set new benchmarks for assessing sustainability performance. In the context of Industry 4.0 and 5.0, there is a growing need to rethink sustainability assessment as a tool that not only guides the digitalization process but also ensures that sustainable practices are integrated effectively. This paper introduces the concept of “digitainability”, representing the convergence of sustainability and digital transformation, shaping future manufacturing paradigms. The DigiSustain Manufacturing Assessment Model (DSMAM) provides a comprehensive framework for evaluating sustainability performance by addressing both the environmental impacts and the digital transformation of manufacturing systems. The model focuses on reducing resource consumption and enhancing operational efficiency through digital innovation, offering strategies for redesigning and reengineering manufacturing processes. It also offers insights for redesigning and reengineering manufacturing processes, identifying opportunities for sustainable digital advancements that drive the development of the factory of the future.