Current pharmaceutical last-mile delivery systems often rely on outdated manual processes and paper-based documentation, leading to significant inefficiencies and security vulnerabilities. This paper proposes a comprehensive framework that leverages smart contracts, blockchain technology, and crowdsourcing to enhance the traceability and security of pharmaceutical deliveries. By utilizing blockchain, the framework automates order processing, tracking, and delivery, ensuring a transparent and tamper-proof record of each transaction. Additionally, the framework incorporates a flexible, crowd-sourced model for selecting carriers through a competitive bidding mechanism, improving efficiency and responsiveness. Our research includes a site visit to a drug distribution company to analyze the existing delivery process and identify critical issues. Based on these insights, we developed a solution that integrates digital and physical tracking measures, such as reusable drug packaging with sensors. The solution was tested locally in a simulated blockchain environment to validate its functionality. The paper emphasizes the need for tailored studies to address international regulatory differences and ethical implications in implementing a blockchain-based pharmaceutical delivery system. This approach not only simplifies the delivery process but also ensures enhanced visibility, reliability, and accountability across the supply chain.