Mining is a fundamental economic activity in Mexico, but it generates waste known as mine tailings, which contain heavy metalsHeavy metals such as lead (Pb) and zinc (Zn). If not properly treated, these metals can contaminate soils and waters. This study evaluates the effectiveness of the glycine-citrate systemGlycine-Citrate System in leaching Pb and Zn from mine tailings. Glycine and citrate form a system that enhances the extraction of these metals by keeping them in solution. The samples were characterized using ICP-MS, XRD, and SEM–EDS to determine the content and mineralogy of Pb and Zn. The concentrations of glycine and citrate were analyzed. The results showed a maximum recovery of 80% for Pb with 0.1 M glycine and 0.1 M citrate, and a recovery of 22.17% for Zn with 0.05 M glycineLead-Zinc and 0.1 M citrate, both at 4 h of reaction.