Research on additive manufacturingAdditive manufacturing (AM) of alloys such as Ti–6Al–4V has increased recently, particularly for aerospace and biomedical applications. Despite the near-net shape advantages of this process, post-processing techniques, such as hot isostatic pressing, are often required to mitigate defects caused by high-temperatureTemperature gradients associated with AM process. In this study, the hot deformationHot deformation response of laser powder bed fusionLaser Powder Bed Fusion (LPBF)-fabricated Ti–6Al–4V was investigated using a GleebleGleeble 563 thermomechanical system to simulate the effects of the HIP process. Quasi-static mechanical response was assessed at a strain rate of 0.01 s⁻1, with deformation temperaturesTemperature ranging from 550 to 800 °C. Results showed that lower deformation temperaturesTemperature led to increased flow stress. These deformation conditions also influenced the microstructureMicrostructure, resulting in fragmentation and changes in the shape of the α-laths. Electron backscatter diffraction (EBSD) analysis revealed that the deformation temperatureTemperature affected the alloy’s crystallographic texture, with a strong orientation preference (i.e., with respect to building direction) observed in the α-laths.