Exposure to UV radiation leads to skin damage, encompass aging, sunburn, and even skin cancer. Crystalline TiO2 has been widely used as a UV blocker but poses certain challenges like skin damage due to its photocatalytic activity. Nanoparticles of titanium dioxide (TiO2) is extensively utilized and favoured in a variety of cosmetic products, including sunscreens as alternatives to crystalline counterpart as well as organic UV filters. Hybridization of TiO2 with biopolymer such as lignin or any other heterogeneous polymer such as melanoidin have shown to efficiently enhance the UV protection ability. Moreover, the use of hybrid nanocomposites can mitigate the white cast effect caused by TiO2, indicating a more promising application of TiO2 in cosmetic products. This chapter intends to present a comprehensive picture on the UV protection by TiO2 nanoparticles. It also proposes to cover the recent developments in the synthesis of multi-functionalised hybrid TiO2 nanomaterials as an alternative and viable option for sunscreens.