This chapter uses Shakespeare’s Othello as a case study of how one might perform a neurological analysis of literature. It first treats the potential neurodivergence of central characters Iago and Othello, demonstrating how any literary figure might be understood via their neurological identity. It then treats the entwined matters of cognition, emotion, and sensation more generally in the play, to illustrate how we might broadly read a text in terms of neurodiversity.