Today, our world has become a digital, interconnected space. Social relationships in the physical natural world have been transformed into virtual social connections. This new situation created new hybrid threatening conditions. Consequently, cybercrime and Cybersecurity emerge as prime causes of concern to nations, societies, and individuals. Although technology may seem the crucial interface between these issues and individuals, the human factor stands as the pivotal yet vulnerable factor. The present chapter aims to be comprehensive, examining the complex facets of the Human Factor (HF) in cybercrime and Cybersecurity and combining diverse approaches to unveil the criminal and victim facets of the cyberhuman act. The chapter highlights that beyond cybercrime and Cybersecurity, human behavior, vulnerabilities, personality characteristics, emotions, and motives have the most critical impact. It addresses the evolving and intricate crosses between technological advancements and human behaviors and thoroughly investigates the multifaceted interplay between humans and cyberspace.