A bus passenger compartment is exposed to significant thermal loads in both hot and cold environment. The climate control system is high power consumer in any vehicle, especially in buses because of the passenger compartment size. An electrification of the buses and pressure to reduce fossil fuel consumption is motivation to improve energy management for comfort systems in any kind of vehicles. In this paper, the identification and discussion of the causes of thermal discomfort and proposal for improvements are presented, based on the experimental investigation of microclimate conditions in a school bus in warm outdoor conditions. Analysis of the individual microclimatic parameters was used as the input for conventional and non-conventional solutions that contribute to improve of the thermal conditions in the passenger compartment. The results showed that some significant changes in design of the vehicle body and the air-conditioning system could improve the energy efficiency of the thermal comfort.