This chapter first provides a section on artificial intelligence (AI) in high risk systems, giving an overview over the current progress in standards relating to this topic. Next, a section addresses explainable AI (XAI) both as a technical concept and as a concept that has evident human and organizational sides to it. Lastly, a section on the concept of safety of intended functionality (SOTIF) is provided as it addresses safety in AI-driven systems, especially autonomous vehicles. This approach helps mitigate risks from functional insufficiencies in AI algorithms, making it vital for deploying AI safely in high risk areas.