Three debated treatments/management strategies in the treatment of ileocolic intussusception were discussed as areas for potential clarification or improvement, including prophylactic antibiotics, delayed repeat enema (DRE) and emergency department (ED) observation versus inpatient admission following non-operative reduction. Our review of the literature found that antibiotics were historically employed to decrease the potential risk of post-reduction infectious complications. There were no studies which provided sufficient data to support the use of antibiotics prior to enema reduction in otherwise healthy and clinically stable children. DRE refers to the use repeated attempts at reduction when the first attempt has failed. Multiple studies have found that DRE is not only safe but also decreases the likelihood of operative intervention. It is particularly successful when each attempt shows progressive reduction of the intussusception. The timing between attempts has a wide range in the articles we reviewed. Our findings suggest that highest chance of success occurs within a window of 30 min to 4 h between attempts. Lastly, we found that for children who undergo non-operative reduction, ED observation for a short interval of time results in decreased length of stay, hospital costs and does not result in an increase of post reduction complications or recurrence and is therefore a safe alternative to inpatient admission.